Antibody Clonality:
Polyclonal
Storage:
Store at -20°C. Avoid freeze / thaw cycles.
1 / 2
2 / 2
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This product comes from:
United States.
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Further Information
EHT, MTGR1, ZMYND3, p85, protein CBFA2T2, CBFA2/RUNX1 translocation partner 2, ETO homolog on chromosome 2ETO homologous on chromosome 2MTG8-like protein, MTG8-related protein 1, core-binding factor, runt domain, alpha subunit 2; translocated to, 2, myeloid translocation gene-related protein 1, myeloid translocation-related protein 1
WB: 1:500 - 1:2000
IF: 1:50 - 1:100
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 325-604 of human CBFA2T2 (NP_005084.1).
9139
CBFA2/RUNX1 partner transcriptional co-repressor 2
CBFA2T2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 72kDa
Affinity purification
Other
O43439
Optimal dilutions for each application to be determined by the researcher.