Further Information
myosin, light polypeptide kinase, myosin light chain kinase, MSTP083, MLCK210, MLCK108, MLCK, KRP, FLJ12216, DKFZp686I10125, myosin, light chain kinase, MYLK, MLCK1, MYLK1
WB: 1:500 - 1:2000
IHC: 1:50 - 1:100
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 1765-1914 of human MYLK (NP_444253.3).
4638
myosin light chain kinase
MYLK
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 170kDa
Affinity purification
Cell Cycle, Signal Transduction
Q15746
Optimal dilutions for each application to be determined by the researcher.