TargetMol

PTUPB

Product Code:
 
TAR-T12580
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T12580-1mg1mg£179.00
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TAR-T12580-5mg5mg£303.00
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TAR-T12580-1mL1 mL * 10 mM (in DMSO)£348.00
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TAR-T12580-10mg10mg£462.00
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TAR-T12580-25mg25mg£711.00
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TAR-T12580-50mg50mg£946.00
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TAR-T12580-100mg100mg£1,259.00
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This product comes from: United States.
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Further Information

Bioactivity:
PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).
CAS:
1287761-01-6
Formula:
C26H24F3N5O3S
Molecular Weight:
543.57
Pathway:
Neuroscience; Metabolism; Immunology/Inflammation
Purity:
0.9915
SMILES:
NS(=O)(=O)c1ccc(cc1)-n1nc(CCCNC(=O)Nc2ccc(cc2)C(F)(F)F)cc1-c1ccccc1
Target:
COX; Epoxide Hydrolase

References

1. Sun CC, et al. PTUPB ameliorates high-fat diet-induced non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in mice. Biochem Biophys Res Commun.?2020?Mar 19;523(4):1020-1026. 2. Zhang G, et al. Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. Proc Natl Acad Sci U S A.?2014 Jul 29;111(30):11127-32. 3. Hwang SH, et al. Synthesis and structure-activity relationship studies of urea-containing pyrazoles as?dual?inhibitors of?cyclooxygenase-2?and?soluble?epoxide?hydrolase.J Med Chem.?2011 Apr 28;54(8):3037-50.