TargetMol

Tat-NR2B9c

Product Code:
 
TAR-T13112
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
 

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CodeSizePrice
TAR-T13112-1mg1mg£122.00
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TAR-T13112-5mg5mg£201.00
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TAR-T13112-10mg10mg£271.00
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TAR-T13112-25mg25mg£461.00
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This product comes from: United States.
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Further Information

Bioactivity:
Tat-NR2B9c is a 20-aa peptide, and acts as a postsynaptic density-95 (PSD-95) inhibitor(EC50 of 6.7 nM for PSD-95d2), and possesses neuroprotective efficacy.
CAS:
500992-11-0
Formula:
C105H188N42O30
Molecular Weight:
2518.88
Purity:
0.98
SMILES:
0

References

1. Cui H, et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci. 2007 Sep 12;27(37):9901-15. 2. Fan J, et al. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease. Neurobiol Dis. 2012 Mar;45(3):999-1009. 3. Teves LM, et al. Efficacy of the PSD95 inhibitor Tat-NR2B9c in mice requires dose translation between species. J Cereb Blood Flow Metab. 2016 Mar;36(3):555-61. 4. Huang LE, et al. N-methyl D-aspartate receptor subtype 2B antagonist, Ro 25-6981, attenuates neuropathic pain by inhibiting postsynaptic density 95 expression. Sci Rep. 2018 May 18;8(1):7848.