TargetMol

TMP-778

Product Code:
 
TAR-T13172L1
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T13172L1-1mg1mg£309.00
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TAR-T13172L1-5mg5mg£566.00
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TAR-T13172L1-1mL1 mL * 10 mM (in DMSO)£683.00
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TAR-T13172L1-10mg10mg£815.00
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TAR-T13172L1-25mg25mg£1,187.00
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TAR-T13172L1-50mg50mg£1,572.00
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This product comes from: United States.
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Further Information

Bioactivity:
TMP-778 is a selective inverse agonist of RORγt.
CAS:
1422171-08-1
Formula:
C31H30N2O4
Molecular Weight:
494.59
Pathway:
Metabolism
Purity:
0.98
SMILES:
CC1=C(C(O)C2=CC3=CC(CC(=O)NC(C4=CC=CC=C4)C4=CC=C(C)C=C4C)=CC=C3O2)C(C)=NO1
Target:
ROR

References

1. Jill Skepner, et al. Pharmacologic inhibition of ROR?t regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo. J Immunol. 2014 Mar 15;192(6):2564-75. 2. Sheng Xiao, et al. Small-molecule ROR?t antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity.2014 Apr 17;40(4):477-89.