TargetMol

CE-245677

Product Code:
 
TAR-T14921
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14921-1mg1mg£115.00
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TAR-T14921-2mg2mg£134.00
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TAR-T14921-5mg5mg£168.00
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TAR-T14921-1mL1 mL * 10 mM (in DMSO)£181.00
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TAR-T14921-10mg10mg£229.00
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TAR-T14921-25mg25mg£335.00
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TAR-T14921-50mg50mg£436.00
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TAR-T14921-100mg100mg£610.00
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This product comes from: United States.
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Further Information

Bioactivity:
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.
CAS:
717899-97-3
Formula:
C24H22Cl2N6O3
Molecular Weight:
513.38
Pathway:
Tyrosine Kinase/Adaptors
Purity:
0.9899
SMILES:
COc1ccc(cc1NC(=O)Nc1ccc(Cl)cc1Cl)C(=O)c1cn(C(C)C)c2ncnc(N)c12
Target:
Tie-2; Trk receptor

References

1. Susan LaGreca, et al. Identification of selective, orally active Tie2 kinase inhibitors and discovery of CE-245,677 and PF-371,989. Cancer Research. AACR Annual Meeting-Apr 14-18, 2007.