TargetMol

NVP-2

Product Code:
 
TAR-T16363
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16363-1mg1mg£111.00
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TAR-T16363-2mg2mg£128.00
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TAR-T16363-5mg5mg£168.00
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TAR-T16363-1mL1 mL * 10 mM (in DMSO)£181.00
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TAR-T16363-10mg10mg£242.00
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TAR-T16363-25mg25mg£442.00
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TAR-T16363-50mg50mg£619.00
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TAR-T16363-100mg100mg£852.00
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Further Information

Bioactivity:
NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases (IC50: 0.584 μM, 0.706 μM, and 0.605 μM, respectively).
CAS:
1263373-43-8
Formula:
C27H37ClN6O2
Molecular Weight:
513.08
Pathway:
Cell Cycle/Checkpoint; Apoptosis
Purity:
0.9976
SMILES:
COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1
Target:
Apoptosis; CDK

References

1. Winter GE, et al. BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment.Mol Cell. 2017 Jul 6;67(1):5-18.e19.