TargetMol

TX1-85-1

Product Code:
 
TAR-T17182
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T17182-1mg1mg£128.00
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TAR-T17182-5mg5mg£195.00
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TAR-T17182-10mg10mg£294.00
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TAR-T17182-25mg25mg£429.00
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TAR-T17182-50mg50mg£598.00
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Further Information

Bioactivity:
TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM). TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3.
CAS:
1603845-32-4
Formula:
C32H36N8O3
Molecular Weight:
580.693
Pathway:
JAK/STAT signaling; Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.9812
SMILES:
CC(=O)N1CCN(CC1)C1CCC(CC1)n1nc(-c2ccc(Oc3ccccc3)c(NC(=O)C=C)c2)c2c(N)ncnc12
Target:
EGFR

References

1. Xie T, et al. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec;10(12):1006-12.