TargetMol

Val-Cit-PAB-MMAE

Product Code:
 
TAR-T18867
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T18867-5mg5mg£111.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T18867-1mL1 mL * 10 mM (in DMSO)£188.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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Further Information

Bioactivity:
Val-Cit-PAB-MMAE is a?drug-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE . MMAE?a potent?mitotic?inhibitor by inhibiting tubulin polymerization[1].
CAS:
644981-35-1
Formula:
C58H94N10O12
Molecular Weight:
1123.448
Purity:
0.9906
SMILES:
CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](N)C(C)C)cc1)C(C)C

References

1. Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16(3), 888-897.