TargetMol

Lexibulin

Product Code:
 
TAR-T2090
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2090-1mg1mg£105.00
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TAR-T2090-5mg5mg£148.00
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TAR-T2090-1mL1 mL * 10 mM (in DMSO)£160.00
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TAR-T2090-10mg10mg£217.00
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TAR-T2090-25mg25mg£366.00
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TAR-T2090-50mg50mg£525.00
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TAR-T2090-100mg100mg£724.00
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Further Information

Bioactivity:
Lexibulin(CYT-997) is a potent tubulin polymerization inhibitor (IC50: 10-100 nM, in Y cell lines). Lexibulin blocks the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death.
CAS:
917111-44-5
Formula:
C24H30N6O2
Molecular Weight:
434.544
Pathway:
Apoptosis; NF-κb; Immunology/Inflammation; Cytoskeletal Signaling; Metabolism
Purity:
0.9922
SMILES:
CCC[C@H](Nc1nc(ncc1C)-c1ccc(NC(=O)NCC)c(OC)c1)c1cccnc1
Target:
Apoptosis; Reactive Oxygen Species; Microtubule Associated

References

1. Burns CJ, et al. Mol Cancer Ther, 2009, 8(11), 3036-3045. 2. Monaghan K, et al. Invest New Drugs, 2011, 29(2), 232-238.