TargetMol

Alflutinib

Product Code:
 
TAR-T22254
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
 

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CodeSizePrice
TAR-T22254-1mg1mg£251.00
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TAR-T22254-5mg5mg£438.00
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TAR-T22254-1mL1 mL * 10 mM (in DMSO)£544.00
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TAR-T22254-10mg10mg£595.00
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TAR-T22254-25mg25mg£863.00
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TAR-T22254-50mg50mg£1,187.00
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Quantity:
TAR-T22254-100mg100mg£1,581.00
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This product comes from: United States.
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Further Information

Bioactivity:
Alflutinib is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.
CAS:
1869057-83-9
Formula:
C28H31F3N8O2
Molecular Weight:
568.59
Pathway:
Tyrosine Kinase/Adaptors; JAK/STAT signaling; Angiogenesis; Metabolism
Purity:
0.9961
SMILES:
CN(C)CCN(C)c(nc(c(Nc1nc(-c2cn(C)c3c2cccc3)ccn1)c1)OCC(F)(F)F)c1NC(C=C)=O
Target:
EGFR; P45

References

1. Liu XY, et al. Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer. Acta Pharmacol Sin. 2020 Oct;41(10):1366-1376.