TargetMol

GSK-114

Product Code:
 
TAR-T22341
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T22341-1mg1mg£119.00
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TAR-T22341-2mg2mg£139.00
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TAR-T22341-5mg5mg£173.00
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TAR-T22341-1mL1 mL * 10 mM (in DMSO)£193.00
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TAR-T22341-10mg10mg£229.00
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TAR-T22341-25mg25mg£436.00
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TAR-T22341-50mg50mg£610.00
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TAR-T22341-100mg100mg£838.00
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TAR-T22341-500mg500mg£1,613.00
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Further Information

Bioactivity:
GSK-114 is a selective inhibitor of TNNI3 interacting kinase (TNNI3K) with an IC50 of 25 nM, 40-fold significant bias for TNNI3K compared to B-Raf with an IC50 of 1000 nM, so GSK-114 has excellent Broad-spectrum kinase selectivity and sufficient oral exposure enable use in cellular and in vivo studies.
CAS:
1301761-96-5
Formula:
C19H23N5O4S
Molecular Weight:
417.48
Purity:
0.9803
SMILES:
CNS(c(cc1)cc(Nc(c2c3)ncnc2cc(OC)c3OC)c1N(C)C)(=O)=O

References

1. Brian G. Lawhorna, Joanne Philpa, et al. GSK114: A selective inhibitor for elucidating the biological role of TNNI3K. Bioorganic & Medicinal Chemistry Letters. Volume 26, Issue 14, 15 July 2016, Pages 3355-3358