TargetMol

Adibendan

Product Code:
 
TAR-T23638
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23638-1mg1mg£227.00
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TAR-T23638-2mg2mg£306.00
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TAR-T23638-1mL1 mL * 10 mM (in DMSO)£410.00
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TAR-T23638-5mg5mg£431.00
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TAR-T23638-10mg10mg£600.00
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TAR-T23638-25mg25mg£863.00
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TAR-T23638-50mg50mg£1,187.00
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TAR-T23638-100mg100mg£1,581.00
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TAR-T23638-500mg500mg£3,107.00
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Further Information

Bioactivity:
Adibendan is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.
CAS:
100510-33-6
Formula:
C16H14N4O
Molecular Weight:
278.31
Pathway:
Metabolism
Purity:
0.9961
SMILES:
O=C1NC2=CC=3N=C(NC3C=C2C1(C)C)C=4C=CN=CC4
Target:
PDE

References

1. Bethke T, et al. Mechanism of action and cardiotonic activity of a new phosphodiesterase inhibitor, the benzimidazole derivative adibendan (BM 14.478), in guinea-pig hearts. Naunyn Schmiedebergs Arch Pharmacol. 1988 May;337(5):576-82. 2. von der Leyen H, et al. Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations. Naunyn Schmiedebergs Arch Pharmacol. 1991 Jul;344(1):90-100. 3. Reiff K. High-performance liquid chromatographic method for the determination of adibendan in plasma and urine. J Chromatogr. 1987 Nov 27;422:346-52. 4. Peters P, et al. Zentrale H?modynamik unter der neuen positiv inotropen Substanz Adibendan. Daten einer Dosisfindungsstudie [Central hemodynamics of a new positive inotropic substance, adibendan. Data from a dose-finding study]. Arzneimittelforschung. 1990 Jun;40(6):666-8. German.