TargetMol

ETP-45658

Product Code:
 
TAR-T25399
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25399-1mg1mg£122.00
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TAR-T25399-2mg2mg£143.00
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TAR-T25399-5mg5mg£182.00
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TAR-T25399-1mL1 mL * 10 mM (in DMSO)£193.00
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TAR-T25399-10mg10mg£254.00
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TAR-T25399-25mg25mg£414.00
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TAR-T25399-50mg50mg£586.00
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TAR-T25399-100mg100mg£804.00
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TAR-T25399-500mg500mg£1,556.00
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Further Information

Bioactivity:
ETP 45658 is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DNA-PK and mTOR (IC50 values are 70.6 and 152 nM respectively).
CAS:
1198357-79-7
Formula:
C16H17N5O2
Molecular Weight:
311.345
Pathway:
PI3K/Akt/mTOR signaling; DNA Damage/DNA Repair
Purity:
0.9913
SMILES:
Cn1ncc2c(nc(nc12)-c1cccc(O)c1)N1CCOCC1
Target:
DNA-PK; PI3K; mTOR

References

1. Maswadeh et al (2015) Coadministration of dox. and etop. loaded in camel milk phospholipids liposomes showed increased antitumor activity in a murine model. PLoS One 10 2847 PMID: 25926730 2. Link W, Oyarzabal J, Serelde BG, Albarran MI, Rabal O, Cebri? A, Alfonso P, Fominaya J, Renner O, Peregrina S, Soil?n D, Ceballos PA, Hern?ndez AI, Lorenzo M, Pevarello P, Granda TG, Kurz G, Carnero A, Bischoff JR. Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases. J Biol Chem. 2009 Oct 9;284(41):28392-400. doi: 10.1074/jbc.M109.038984. Epub 2009 Aug 18. PubMed PMID: 19690175; PubMed Central PMCID: PMC2788888.