TargetMol

IMM-01

Product Code:
 
TAR-T25529
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25529-1mg1mg£161.00
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TAR-T25529-1mL1 mL * 10 mM (in DMSO)£245.00
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TAR-T25529-5mg5mg£265.00
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TAR-T25529-10mg10mg£346.00
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TAR-T25529-25mg25mg£532.00
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TAR-T25529-50mg50mg£732.00
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TAR-T25529-100mg100mg£978.00
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Quantity:
TAR-T25529-500mg500mg£1,902.00
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This product comes from: United States.
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Further Information

Bioactivity:
IMM-01 is a novel class of small-molecule agonists of the mammalian Diaphanous (mDia)-related formins, which act downstream of Rho GTPases to assemble actin filaments, and their organization with microfilaments to establish and maintain cell polarity during migration and asymmetric division. GTP-bound Rho activates mDia family members by disrupting the interaction between the DID and DAD autoregulatory domains, which releases the FH2 domain to modulate actin and microtubule dynamics[1].
CAS:
218795-74-5
Formula:
C12H17N3O2S
Molecular Weight:
267.35
Pathway:
GPCR/G Protein
Purity:
0.9881
SMILES:
CC(C)(C)NC(=S)NN=Cc1ccc(O)cc1O
Target:
GTPase

References

1. Lash LL, et al. Small-molecule intramimics of formin autoinhibition: a new strategy to target the cytoskeletal remodeling machinery in cancer cells. Cancer Res. 2013 Nov 15;73(22):6793-803. 2. Lash LL, Wallar BJ, Turner JD, Vroegop SM, Kilkuskie RE, Kitchen-Goosen SM, Xu HE, Alberts AS. Small-molecule intramimics of formin autoinhibition: a new strategy to target the cytoskeletal remodeling machinery in cancer cells. Cancer Res. 2013 Nov 15;73(22):6793-803. doi: 10.1158/0008-5472.CAN-13-1593. PubMed PMID: 24242070.