TargetMol

Lateritin

Product Code:
 
TAR-T25635
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25635-1mg1mg£278.00
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TAR-T25635-1mL1 mL * 10 mM (in DMSO)£519.00
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TAR-T25635-5mg5mg£586.00
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TAR-T25635-10mg10mg£804.00
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TAR-T25635-25mg25mg£1,171.00
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TAR-T25635-50mg50mg£1,556.00
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Quantity:
TAR-T25635-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Lateritin is An Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor and a platelet aggregation inhibitor from the mycelial cake of Gibberella lateritium. Bassiatin is the (3S,6R) isomer.
CAS:
65454-13-9
Formula:
C15H19NO3
Molecular Weight:
261.321
Pathway:
Metabolism
Purity:
0.98
SMILES:
CC(C)C1OC(=O)C(Cc2ccccc2)N(C)C1=O
Target:
Acyltransferase

References

1. Pettit RK, Pettit GR, Xu JP, Weber CA, Richert LA. Isolation of human cancer cell growth inhibitory, antimicrobial lateritin from a mixed fungal culture. Planta Med. 2010 Mar;76(5):500-1. doi: 10.1055/s-0029-1240617. Epub 2009 Nov 25. PubMed PMID: 19941263. 2. Hasumi K, Shinohara C, Iwanaga T, Endo A. Lateritin, a new inhibitor of acyl-CoA:cholesterol acyltransferase produced by Gibberella lateritium IFO 7188. J Antibiot (Tokyo). 1993 Dec;46(12):1782-7. PubMed PMID: 8294234. 3. Meng L, Tao H, Dong G, Yang T, Zhang W, Zhu W, Huang C. ERK1/2 and Akt pathway activated during (3R,6R)-bassiatin(1)-induced apoptosis in MCF-7 cells. Cell Biol Int. 2012 Apr 1;36(4):345-8. doi: 10.1042/CBI20110388. PubMed PMID: 22150072. 4. Meng L, Feng B, Tao H, Yang T, Meng Y, Zhu W, Huang C. A novel antioestrogen agent (3R,6R)-bassiatin inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression in 17?-oestradiol-treated MCF-7 cells. Cell Biol Int. 2011 Jun;35(6):599-605. doi: 10.1042/CBI20100765. PubMed PMID: 21241249.