TargetMol

6PGD-IN-S3

Product Code:
 
TAR-T26397
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26397-1mg1mg£177.00
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Quantity:
TAR-T26397-1mL1 mL * 10 mM (in DMSO)£295.00
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Quantity:
TAR-T26397-5mg5mg£313.00
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Quantity:
TAR-T26397-10mg10mg£430.00
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Quantity:
TAR-T26397-25mg25mg£663.00
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Quantity:
TAR-T26397-50mg50mg£863.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
6PGD-IN-S3 is an inhibitor of 6-phosphogluconate dehydrogenase (6PGD).
CAS:
5539-66-2
Formula:
C15H10O4
Molecular Weight:
254.241
Pathway:
Metabolism
Purity:
0.9912
SMILES:
COc1cccc2C(=O)c3cccc(O)c3C(=O)c12
Target:
Dehydrogenase

References

1. YPan, CShan, SWu, et al. Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin[J]. Oncogene, 2017. 2. Lin R, Elf S, Shan C, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96. doi: 10.1038/ncb325Epub 2015 Oct 19. Review. PubMed PMID: 26479318; PubMed Central PMCID: PMC4628560.