TargetMol

JTE-607

Product Code:
 
TAR-T27695
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27695-1mg1mg£100.00
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TAR-T27695-2mg2mg£112.00
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TAR-T27695-5mg5mg£142.00
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TAR-T27695-1mL1 mL * 10 mM (in DMSO)£164.00
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TAR-T27695-10mg10mg£201.00
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TAR-T27695-25mg25mg£348.00
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TAR-T27695-50mg50mg£547.00
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TAR-T27695-100mg100mg£752.00
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Further Information

Bioactivity:
JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.
CAS:
188791-09-5
Formula:
C22H29Cl4N3O3
Molecular Weight:
525.29
Pathway:
Proteases/Proteasome
Purity:
0.9872
SMILES:
Cl.Cl.CCN(C(=O)c1cc(Cl)c(OCCN2CCN(C)CC2)c(Cl)c1O)c1ccccc1
Target:
Cysteine Protease

References

1. Borozdenkova S, Mant TG, Allen E, Pu K, Hoshino S, Jurcevic S. Effects of a cytokine inhibitor, JTE-607, on the response to endotoxin in healthy human volunteers. Int Immunopharmacol. 2011 Nov;11(11):1837-43. doi: 10.1016/j.intimp.2011.07.013. 2. Tajima N, Fukui K, Uesato N, Maruhashi J, Yoshida T, Watanabe Y, Tojo A. JTE-607, a multiple cytokine production inhibitor, induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells. Cancer Sci. 2010 Mar;101(3):774-81. doi: 10.1111/j.1349-7006.2009.01446.x. 3. Asaga T, Ueki M, Chujo K, Taie S. JTE-607, an inflammatory cytokine synthesis inhibitor, attenuates ischemia/reperfusion-induced renal injury by reducing neutrophil activation in rats. J Biosci Bioeng. 2008 Jul;106(1):22-6. doi: 10.1263/jbb.106.22. 4. Uesato N, Fukui K, Maruhashi J, Tojo A, Tajima N. JTE-607, a multiple cytokine production inhibitor, ameliorates disease in a SCID mouse xenograft acute myeloid leukemia model. Exp Hematol. 2006 Oct;34(10):1385-92.