TargetMol

Parsaclisib hydrochloride

Product Code:
 
TAR-T28297
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28297-5mg5mg£331.00
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TAR-T28297-50mg50mg£1,364.00
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TAR-T28297-100mg100mg£2,135.00
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Further Information

Bioactivity:
Parsaclisib HCl is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity with IC50 values ranging from 0.2 to 2 nM.
CAS:
1995889-48-9
Formula:
C20H23Cl2FN6O2
Molecular Weight:
469.34
Pathway:
PI3K/Akt/mTOR signaling
Purity:
0.98
SMILES:
Cl.CCOc1c(cc(Cl)c(F)c1[C@@H]1CNC(=O)C1)[C@H](C)n1nc(C)c2c(N)ncnc12
Target:
PI3K

References

1. Shin N, et al. Abstract 2671: INCB050465, a novel PI3K? inhibitor, synergizes with PIM protein kinase inhibition to cause tumor regression in a model of DLBCL. Cancer Research. 2015, Aug. 75(15) 2. Shin N, et, al. Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase ? Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy. J Pharmacol Exp Ther. 2020 Jul;374(1):211-222. 3. Yue EW, et, al. INCB050465 (Parsaclisib), a Novel Next-Generation Inhibitor of Phosphoinositide 3-Kinase Delta (PI3K?). ACS Med Chem Lett. 2019 Oct 17;10(11):1554-1560.