TargetMol

Ponicidin

Product Code:
 
TAR-T2S1975
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T2S1975-25mg25mgEnquire
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TAR-T2S1975-50mg50mgEnquire
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TAR-T2S1975-1mg1mg£122.00
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TAR-T2S1975-5mg5mg£189.00
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TAR-T2S1975-10mg10mg£246.00
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TAR-T2S1975-1mL1 mL * 10 mM (in DMSO)£309.00
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Further Information

Bioactivity:
Ponicidin is a diterpenoid derived from Rabdosia rubescens. Ponicidin exhibits immunoregulatory, anti-inflammatory, anti-viral, and anti-cancer activity. Ponicidin induces apoptosis of gastric carcinoma cells, decreases the phosphorylation of JAK2 and STAT3, and shows no effect on protein levels of JAK2 and STAT3.
CAS:
52617-37-5
Formula:
C20H26O6
Molecular Weight:
362.42
Pathway:
JAK/STAT signaling; Stem Cells; Angiogenesis; Chromatin/Epigenetic; Apoptosis
Purity:
0.9992
SMILES:
C=C1C([C@@]23[C@](O)(O4)[C@@H](O)[C@]5([H])C(C)(C)CC[C@H](O)[C@@]5([C@@]4([H])O[C@@]3([H])[C@H]1CC6)[C@@]26[H])=O
Target:
Apoptosis; JAK; STAT

References

1. Xiaodan Liu, et al. Apoptosis inducing effect of ponicidin in leukemia K562 cells and its mechanisms of action. Zhongguo Zhong Yao Za Zhi. 2010 Aug;35(16):2161-5. 2. Ponicidin inhibits monocytic leukemia cell growth by induction of apoptosis. Int J Mol Sci. 2008 Nov;9(11):2265-77.