TargetMol

LCB 03-0110 dihydrochloride

Product Code:
 
TAR-T32613
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T32613-1mg1mg£166.00
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TAR-T32613-2mg2mg£213.00
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TAR-T32613-5mg5mg£290.00
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TAR-T32613-1mL1 mL * 10 mM (in DMSO)£336.00
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TAR-T32613-10mg10mg£390.00
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TAR-T32613-25mg25mg£605.00
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TAR-T32613-50mg50mg£831.00
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TAR-T32613-100mg100mg£1,099.00
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Further Information

Bioactivity:
LCB 03-0110 Dihydrochloride is a potent inhibitor of the c-Src kinase (IC50 = 1.3 nM) and tyrosine kinases in the BTK and SYK family, as well as in the DDR2 family. It inhibits LPS-induced activation of macrophages and TGF-β1-induced activation of fibroblasts in vitro, inhibits activation of macrophages and fibroblasts, and inhibits scarring in wound healing models.
CAS:
1962928-28-4
Formula:
C24H25Cl2N3O2S
Molecular Weight:
490.45
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors
Purity:
0.9976
SMILES:
Cl.Cl.Oc1cccc(Nc2ccnc3cc(sc23)-c2cccc(CN3CCOCC3)c2)c1
Target:
Src

References

1. Sun X, Phan TN, Jung SH, Kim SY, Cho JU, Lee H, Woo SH, Park TK, Yang BS. LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation. J Pharmacol Exp Ther. 2012 Mar;340(3):510-9. doi: 10.1124/jpet.111.187328. Epub 2011 Nov 29. PMID: 22128347.