TargetMol

Merodantoin

Product Code:
 
TAR-T33296
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T33296-1mg1mg£227.00
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TAR-T33296-1mL1 mL * 10 mM (in DMSO)£385.00
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TAR-T33296-5mg5mg£422.00
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TAR-T33296-10mg10mg£589.00
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TAR-T33296-25mg25mg£863.00
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TAR-T33296-50mg50mg£1,179.00
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Quantity:
TAR-T33296-100mg100mg£1,564.00
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TAR-T33296-500mg500mg£3,058.00
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This product comes from: United States.
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Further Information

Bioactivity:
Merodantoin is an apoptosis inducer and triggers cell apoptosis associated with ROS-dependent autophagy. Merodantoin targets cancer cells expressing KRAS mutations involved in Akt-dependent ROS production.
CAS:
143413-73-4
Formula:
C11H18N2O2S
Molecular Weight:
242.34
Pathway:
Apoptosis
Purity:
0.98
SMILES:
CCCCN1C(=O)C(=O)N(CCCC)C1=S
Target:
Apoptosis

References

Sharma R, Arnold L, Gulliya KS. Correlation between DNA topoisomerase II activity and cytotoxicity in pMC540 and merodantoin sensitive and resistant human breast cancer cells. Anticancer Res. 1995 Mar-Apr;15(2):295-304. PubMed PMID: 7762997. Gulliya KS, Sharma R, Liu HW, Arnold L, Matthews JL. Relationship of mitochondrial function and cellular adenosine triphosphate levels to pMC540 and merodantoin cytotoxicity in MCF-7 human breast cancer cells. Anticancer Drugs. 1995 Aug;6(4):545-52. PubMed PMID: 7579558. Iskandar K, Rezlan M, Yadav SK, Foo CH, Sethi G, Qiang Y, Bellot GL, Pervaiz S. Synthetic Lethality of a Novel Small Molecule Against Mutant KRAS-Expressing Cancer Cells Involves AKT-Dependent ROS Production. Antioxid Redox Signal. 2016 May 10;24(14):781-94. doi: 10.1089/ars.2015.6362. Epub 2016 Feb 26. PubMed PMID: 26714745. Sharma R, Gulliya KS. Growth inhibitory effects of pMC540 and merodantoin on established MCF-7 human breast tumor xenografts. In Vivo. 1995 Mar-Apr;9(2):103-8. PubMed PMID: 7548784.