TargetMol

MSC 2032964A

Product Code:
 
TAR-T33514
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T33514-1mg1mg£173.00
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TAR-T33514-5mg5mg£285.00
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TAR-T33514-1mL1 mL * 10 mM (in DMSO)£320.00
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TAR-T33514-10mg10mg£410.00
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TAR-T33514-25mg25mg£624.00
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TAR-T33514-50mg50mg£858.00
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Quantity:
TAR-T33514-100mg100mg£1,155.00
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Further Information

Bioactivity:
MSC 2032964A is a potent selective ASK1 inhibitor (IC50 = 93 nM) that is oral bioavailable and brain permeable. It inhibited neuroinflammation in mouse EAE models and blocked LPS-induced phosphorylation of ASK1 and p38 in cultured mouse astrocytes.
CAS:
1124381-43-6
Formula:
C16H13F3N6O
Molecular Weight:
362.316
Pathway:
Apoptosis
Purity:
1
SMILES:
FC(F)(F)c1cc(NC2CC2)n2nc(NC(=O)c3cccnc3)nc2c1
Target:
ASK

References

Kawarazaki Y, Ichijo H, Naguro I. Apoptosis signal-regulating kinase 1 as a therapeutic target. Expert Opin Ther Targets. 2014 Jun;18(6):651-64.