TargetMol

BMS-582949 hydrochloride

Product Code:
 
TAR-T3462
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3462-1mg1mg£109.00
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TAR-T3462-2mg2mg£130.00
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TAR-T3462-1mL1 mL * 10 mM (in DMSO)£166.00
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TAR-T3462-5mg5mg£168.00
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TAR-T3462-10mg10mg£230.00
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TAR-T3462-25mg25mg£402.00
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TAR-T3462-50mg50mg£564.00
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TAR-T3462-100mg100mg£774.00
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Further Information

Bioactivity:
The BMS-582949 hydrochloride is a highly specific p38α MAPK inhibitor (IC50: 13 nM).
CAS:
912806-16-7
Formula:
C22H27ClN6O2
Molecular Weight:
442.95
Pathway:
Autophagy; MAPK
Purity:
0.9757
SMILES:
Cl.CCCNC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)NC3CC3)c2c1C
Target:
p38 MAPK; Autophagy

References

Liu C, et al. Discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a clinical p38? MAP kinase inhibitor for the treatment of inflammatory diseases. J Med Chem. 2010 Sep 23;53(18):6629-39. Emami H, et al. The effect of BMS-582949, a P38 mitogen-activated protein kinase (P38 MAPK) inhibitor on arterial inflammation: a multicenter FDG-PET trial. Atherosclerosis. 2015 Jun;240(2):490-6.