TargetMol

SYR127063

Product Code:
 
TAR-T34760
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T34760-1mg1mg£177.00
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TAR-T34760-5mg5mg£313.00
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TAR-T34760-1mL1 mL * 10 mM (in DMSO)£370.00
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TAR-T34760-10mg10mg£434.00
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TAR-T34760-25mg25mg£670.00
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Quantity:
TAR-T34760-50mg50mg£914.00
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This product comes from: United States.
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Further Information

Bioactivity:
SYR127063 (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.
CAS:
871026-18-5
Formula:
C23H20ClF3N4O3
Molecular Weight:
492.88
Pathway:
Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Purity:
0.9857
SMILES:
OCCOCCn1ccc2ncnc(Nc3ccc(Oc4cccc(c4)C(F)(F)F)c(Cl)c3)c12
Target:
EGFR; HER

References

Aertgeerts K, Skene R, Yano J, Sang BC, Zou H, Snell G, Jennings A, Iwamoto K, Habuka N, Hirokawa A, Ishikawa T, Tanaka T, Miki H, Ohta Y, Sogabe S. Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein. J Biol Chem. 2011 May 27;286(21):18756-65. doi: 10.1074/jbc.M110.206193. Epub 2011 Mar 30. PubMed PMID: 21454582; PubMed Central PMCID: PMC3099692.