TargetMol

C29

Product Code:
 
TAR-T3502
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3502-1mg1mg£108.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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TAR-T3502-5mg5mg£149.00
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TAR-T3502-1mL1 mL * 10 mM (in DMSO)£193.00
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TAR-T3502-10mg10mg£222.00
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TAR-T3502-25mg25mg£367.00
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TAR-T3502-50mg50mg£525.00
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Quantity:
TAR-T3502-100mg100mg£724.00
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Further Information

Bioactivity:
C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages.
CAS:
363600-92-4
Formula:
C16H15NO4
Molecular Weight:
285.299
Pathway:
Immunology/Inflammation
Purity:
0.98
SMILES:
COc1cccc(C=Nc2cccc(C(O)=O)c2C)c1O
Target:
TLR

References

Mistry P, et al. Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5455-60. Du J, Li J, Zhu J, et al. Structural characterization and immunomodulatory activity of a novel polysaccharide from Ficus carica. Food & function. 2018 Jul 17;9(7):3930-3943. Du J, Li J, Zhu J, et al. Structural characterization and immunomodulatory activity of a novel polysaccharide from Ficus carica[J]. Food & function. 2018 Jul 17;9(7):3930-3943. Li Y, Niu M, Zhao A, et al. CXCL12 is involved in ?-synuclein-triggered neuroinflammation of Parkinson?s disease. Journal of Neuroinflammation. 2019, 16(1): 1-14 Li Y, Niu M, Zhao A, et al. CXCL12 is involved in ?-synuclein-triggered neuroinflammation of Parkinson?s disease[J]. Journal of Neuroinflammation. 2019, 16(1): 1-14. Jiang S, Yin H, Qi X, et al. Immunomodulatory effects of fucosylated chondroitin sulfate from Stichopus chloronotus on RAW 264.7 cells[J]. Carbohydrate Polymer. 2020, 251: 117088. Wen Y, Peng D, Li C, et al. A new polysaccharide isolated from Morchella importuna fruiting bodies and its immunoregulatory mechanism[J]. International Journal of Biological Macromolecules. 2019, 137: 8-19. Nie K, Zhang C, Deng M, et al. A Series of Genes for Predicting Responses to Anti-Tumor Necrosis Factor ? Therapy in Crohn?s Disease. Frontiers in Pharmacology. 2022: 1195 Jiang S, Yin H, Qi X, et al. Immunomodulatory effects of fucosylated chondroitin sulfate from Stichopus chloronotus on RAW 264.7 cells. Carbohydrate Polymer. 2020, 251: 117088. Wen Y, Peng D, Li C, et al. A new polysaccharide isolated from Morchella importuna fruiting bodies and its immunoregulatory mechanism. International Journal of Biological Macromolecules. 2019, 137: 8-19. Zhang R, Tang L, Wang Y, et al.A Dendrimer Peptide (KK2DP7) Delivery System with Dual Functions of Lymph Node Targeting and Immune Adjuvants as a General Strategy for Cancer Immunotherapy.Advanced Science.2023: 2300116.