TargetMol

N-Oleoyl Glutamine

Product Code:
 
TAR-T36064
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36064-1mg1mg£124.00
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TAR-T36064-5mg5mg£307.00
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TAR-T36064-10mg10mg£519.00
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TAR-T36064-25mg25mg£1,058.00
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This product comes from: United States.
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Further Information

Bioactivity:
N-Oleoyl glutamine is an endogenous N-acyl amine.1,2It is both formed and degraded by peptidase M20 domain-containing 1 (PM20D1), a factor secreted by thermogenic adipose cells. N-Oleoyl glutamine (50 μM) induces mitochondrial uncoupling to increase respiration in C2C12 cells by 64%.3It inhibits capsaicin-induced calcium flux in HEK293A cells co-transfected with transient receptor potential vanilloid 1 (TRPV1) and red fluorescent protein (RFP).2N-Oleoyl glutamine (100 mg/kg) reduces the number of acetic acid-induced abdominal constrictions, as well as formalin-induced paw licking in mice.
CAS:
247150-73-8
Formula:
C23H42N2O4
Molecular Weight:
410.6
Purity:
0.98
SMILES:
O=C(CCCCCCC/C=CCCCCCCCC)N[C@H](C(O)=O)CCC(N)=O

References

Long, J.Z., Svensson, K.J., Bateman, L.A., et al.The secreted enzyme PM20D1 regulates lipidated amino acid uncouplers of mitochondriaCell166(2)1-12(2016) Lin, H., Long, J.Z., Roche, A.M., et al.Discovery of hydrolysis-resistant isoindoline N-acyl amino acid analogues that stimulate mitochondrial respirationJ. Med. Chem.61(7)3224-3230(2018) Long, J.Z., Roche, A.M., Berdan, C.A., et al.Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociceptionProc. Natl. Acad. Sci. U.S.A.115(29)E6937-E6945(2018)