TargetMol

(E)-SIS3

Product Code:
 
TAR-T3636
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3636-1mg1mg£99.00
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TAR-T3636-2mg2mg£112.00
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TAR-T3636-5mg5mg£161.00
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TAR-T3636-1mL1 mL * 10 mM (in DMSO)£169.00
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TAR-T3636-10mg10mg£212.00
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TAR-T3636-25mg25mg£362.00
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TAR-T3636-50mg50mg£503.00
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TAR-T3636-100mg100mg£687.00
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Quantity:
TAR-T3636-500mg500mg£1,315.00
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Further Information

Bioactivity:
SIS3, a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts and inhibits TGF-β2-induced endothelial cell differentiation in iPSCs.
CAS:
521984-48-5
Formula:
C28H28ClN3O3
Molecular Weight:
490
Pathway:
Stem Cells
Purity:
0.9883
SMILES:
Cl.COc1cc2CCN(Cc2cc1OC)C(=O)C=Cc1c(-c2ccccc2)n(C)c2ncccc12
Target:
TGF-beta/Smad

References

Xu J, Ma L, Wang D, et al. Uncarboxylated osteocalcin promotes proliferation and metastasis of MDA-MB-231 cells through TGF-?/SMAD3 signaling pathway. BMC Molecular and Cell Biology. 2022, 23(1): 1-17 Li J, et al. Diabetes. 2010, 59(10):2612-24. Jinnin M, et al. Mol Pharmacol. 2006, 69(2):597-607.