TargetMol

Illudin M

Product Code:
 
TAR-T36528
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T36528-1mg1mg£499.00
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TAR-T36528-5mg5mg£1,026.00
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TAR-T36528-10mg10mg£1,340.00
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TAR-T36528-25mg25mg£1,982.00
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TAR-T36528-50mg50mg£2,633.00
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TAR-T36528-100mg100mg£3,548.00
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Further Information

Bioactivity:
Illudin M is a cytotoxic sesquiterpene from the fungus O. illudens that alkylates DNA. It is cytotoxic to HL-60 human leukemia cells at 6-100 nM. Illudin M was used as a base structure for the development of potential anticancer agents with less toxicity and improved efficacy. It is closely related to illudin S , which has been the focus of additional studies.
CAS:
1146-04-9
Formula:
C15H20O3
Molecular Weight:
248.322
Pathway:
Apoptosis|DNA Damage/DNA Repair
Purity:
0.98
SMILES:
CC1=C2[C@@H](O)C(C)(C)C=C2C(=O)[C@](C)(O)C11CC1
Target:
DNA Alkylator/Crosslinker|Apoptosis

References

Le P, et al. A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. Schobert R, et al. Conjugates of the fungal cytotoxin illudin M with improved tumour specificity. Bioorg Med Chem. 2008 Sep 15;16(18):8592-7.