TargetMol

C3a Receptor Agonist

Product Code:
 
TAR-T38287
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T38287-1mg1mg£142.00
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Quantity:
TAR-T38287-5mg5mg£326.00
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TAR-T38287-10mg10mg£503.00
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TAR-T38287-25mg25mg£768.00
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Quantity:
TAR-T38287-50mg50mg£1,010.00
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Quantity:
TAR-T38287-100mg100mg£1,340.00
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Quantity:
TAR-T38287-500mg500mg£2,617.00
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This product comes from: United States.
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Further Information

Bioactivity:
C3a Receptor Agonist binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway. Activation of C3aR prevents neutrophils from being mobilized in a model of intestinal ischemia-reperfusion injury. C3aRs are expressed on neural progenitor cells and immature neurons in adult mice. C3a stimulates differentiation of neural progenitor cells in vitro.
CAS:
944997-60-8
Formula:
C27H35N3O2
Molecular Weight:
433.59
Pathway:
Immunology/Inflammation
Purity:
0.975
SMILES:
O=C(N1CCC(NC(=O)C(C=2C=CC=CC2)C3CCCCC3)CC1)CCC=4C=NC=CC4
Target:
Complement System

References

Rahpaymai, Y., Hietala, M.A., Wilhelmsson, U., et al. Complement: A novel factor in basal and ischemia-induced neurogenesis. EMBO J. 25(6), 1364-1374 (2006). Shinjyo, N., St?hlberg, A., Dragunow, M., et al. Complement-derived anaphylatoxin C3a regulates in vitro differentiation and migration of neural progenitor cells. Stem Cells 27(11), 2824-2832 (2009). Klos, A., Wende, E., Wareham, K.J., et al. International union of basic and clinical pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors. Pharmacol. Rev. 65(1), 500-543 (2013). Wu, M.C.L., Brennan, F.H., Lynch, J.P.L., et al. The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization. Proc. Natl. Acad. Sci. USA 110923), 9439-9444 (2013).