TargetMol

Boc-Asp(OMe)-fluoromethyl ketone

Product Code:
 
TAR-T39308
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T39308-1mg1mg£103.00
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TAR-T39308-1mL1 mL * 10 mM (in DMSO)£146.00
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TAR-T39308-5mg5mg£148.00
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TAR-T39308-10mg10mg£195.00
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TAR-T39308-25mg25mg£322.00
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TAR-T39308-50mg50mg£466.00
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Quantity:
TAR-T39308-100mg100mg£651.00
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Further Information

Bioactivity:
Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor. Boc-Asp(OME)-Fluoromethyl Ketone inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8.
CAS:
187389-53-3
Formula:
C11H18FNO5
Molecular Weight:
263.265
Pathway:
Apoptosis; Proteases/Proteasome
Purity:
0.98
SMILES:
COC(=O)CC(NC(=O)OC(C)(C)C)C(=O)CF
Target:
Caspase

References

Paunel-G?rg?l? A, et al. Stimulation of Fas signaling down-regulates activity of neutrophils from major trauma patients with SIRS. Immunobiology. 2011;216(3):334-342. Koike A, et al. Pan-caspase inhibitors induce necroptosis via ROS-mediated activation of mixed lineage kinase domain-like protein and p38 in classically activated macrophages. Exp Cell Res. 2019;380(2):171-179.