TargetMol

SGC2085 HCl

Product Code:
 
TAR-T4013
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T4013-1mg1mg£139.00
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TAR-T4013-2mg2mg£193.00
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TAR-T4013-5mg5mg£231.00
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TAR-T4013-1mL1 mL * 10 mM (in DMSO)£276.00
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TAR-T4013-10mg10mg£360.00
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TAR-T4013-25mg25mg£550.00
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TAR-T4013-50mg50mg£768.00
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TAR-T4013-100mg100mg£1,026.00
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This product comes from: United States.
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Further Information

Bioactivity:
SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulator of Wnt/β-catenin transcription and neoplastic transformation in colorectal cancer as well as a critical factor in estrogen-stimulated breast cancer growth, and its depletion results in decreased proliferation of myeloid leukemia cells in vivo.
CAS:
1821908-49-9
Formula:
C19H25ClN2O2
Molecular Weight:
348.87
Pathway:
Chromatin/Epigenetic
Purity:
0.9991
SMILES:
Cl.C[C@H](N)C(=O)NCc1ccc(Oc2cc(C)cc(C)c2)c(C)c1
Target:
Histone Methyltransferase

References

Renato., et al. Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening . J Med Chem. 2016 Jul 28;59(14):6838-47.