TargetMol

Q203

Product Code:
 
TAR-T5400
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5400-1mg1mg£118.00
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TAR-T5400-5mg5mg£201.00
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TAR-T5400-1mL1 mL * 10 mM (in DMSO)£230.00
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TAR-T5400-10mg10mg£273.00
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TAR-T5400-25mg25mg£434.00
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TAR-T5400-50mg50mg£606.00
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TAR-T5400-100mg100mg£833.00
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This product comes from: United States.
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Further Information

Bioactivity:
Q203 is a novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB and inhibits M. tuberculosis H37Rv (MIC50: 2.7 nM).
CAS:
1334719-95-7
Formula:
C29H28ClF3N4O2
Molecular Weight:
557.01
Pathway:
Microbiology/Virology
Purity:
0.9947
SMILES:
CCc1nc2ccc(Cl)cn2c1C(=O)NCc1ccc(cc1)N1CCC(CC1)c1ccc(OC(F)(F)F)cc1
Target:
Antibacterial; Antibiotic

References

Jang J, et al. Efflux Attenuates the Antibacterial Activity of Q203 in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e02637-16. Lu P, et al. The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd. Sci Rep. 2018 Feb 8;8(1):2625. Pethe K, et al. Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nat Med. 2013 Sep;19(9):1157-60.