TargetMol

T-5224

Product Code:
 
TAR-T5416
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5416-1mg1mg£103.00
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TAR-T5416-2mg2mg£118.00
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TAR-T5416-5mg5mg£148.00
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TAR-T5416-1mL1 mL * 10 mM (in DMSO)£158.00
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TAR-T5416-10mg10mg£189.00
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TAR-T5416-25mg25mg£285.00
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Quantity:
TAR-T5416-50mg50mg£430.00
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TAR-T5416-100mg100mg£600.00
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Quantity:
TAR-T5416-500mg500mg£1,187.00
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This product comes from: United States.
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Further Information

Bioactivity:
T-5224 is a transcription factor c-Fos/AP-1 inhibitor, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors.
CAS:
530141-72-1
Formula:
C29H27NO8
Molecular Weight:
517.534
Pathway:
Proteases/Proteasome
Purity:
0.9929
SMILES:
OC(=O)CCc1cc(ccc1OCc1ccc2c(c1)o[nH]c2=O)C(=O)c1ccc(OC2CCCC2)cc1O
Target:
MMP

References

Blunsom NJ, et al. Sustained phospholipase C stimulation of H9c2 cardiomyoblasts by vasopressin induces an increase in CDP-diacylglycerol synthase 1 (CDS1) through protein kinase C and cFos. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jul;1864(7):1072-1082. Kamide D, et al. Selective activator protein-1 inhibitor T-5224 prevents lymph node metastasis in an oral cancer model. Cancer Sci. 2016 May;107(5):666-73. Aikawa Y, et al. Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1. Nat Biotechnol. 2008 Jul;26(7):817-23. Izuta S, et al. T-5224, a selective inhibitor of c-Fos/activator protein-1, attenuates lipopolysaccharide-induced liver injury in mice. Biotechnol Lett. 2012 Dec;34(12):2175-82. Wang X, Li K, Cheng M, et al.RNPS1 stabilizes NAT10 protein to facilitate translation in cancer via tRNA ac4C modification.bioRxiv.2023: 2023.02. 11.528122.