TargetMol

GNE-064

Product Code:
 
TAR-T60079
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T60079-1mg1mg£149.00
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TAR-T60079-2mg2mg£187.00
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TAR-T60079-5mg5mg£269.00
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TAR-T60079-1mL1 mL * 10 mM (in DMSO)£279.00
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TAR-T60079-10mg10mg£389.00
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TAR-T60079-25mg25mg£603.00
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TAR-T60079-50mg50mg£830.00
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TAR-T60079-100mg100mg£1,099.00
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Quantity:
TAR-T60079-500mg500mg£2,135.00
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Further Information

Bioactivity:
GNE-064 is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 μM and inhibits SMARCA2 with an EC50 of 0.10 μM. GNE-064 possess Kds with 0.01, 0.016, 0.018 and 0.049 μM for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of drug synthesis.
CAS:
1997321-20-6
Formula:
C17H21N5O2
Molecular Weight:
327.38
Pathway:
Chromatin/Epigenetic
Purity:
0.9981
SMILES:
NC1=C(C=C(N=N1)C2=C(O)C=CC=C2)N3C[C@@H](C)N(C(C)=O)CC3
Target:
Epigenetic Reader Domain

References

Taylor AM, et al. GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1. J Med Chem. 2022 Aug 5.