TargetMol

TTBK1-IN-2

Product Code:
 
TAR-T60086
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T60086-1mg1mg£169.00
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TAR-T60086-5mg5mg£299.00
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TAR-T60086-1mL1 mL * 10 mM (in DMSO)£310.00
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TAR-T60086-10mg10mg£408.00
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TAR-T60086-25mg25mg£631.00
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TAR-T60086-50mg50mg£868.00
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Quantity:
TAR-T60086-100mg100mg£1,139.00
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Quantity:
TAR-T60086-500mg500mg£2,223.00
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This product comes from: United States.
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Further Information

Bioactivity:
TTBK1-IN-2 is an inhibitor of Tau-Tubulin kinase (TTBK1) with IC50s of 0.24 and 4.22 ?M. TTBK1-IN-2 reduces TDP-43 phosphorylation both in cell cultures and the spinal cord of transgenic TDP-43 mice.
CAS:
2765453-51-6
Formula:
C18H13ClN4O
Molecular Weight:
336.77
Pathway:
Cytoskeletal Signaling
Purity:
0.9983
SMILES:
ClC1=CC=C(OC2=CC=C(C=C2)NC=3N=CN=C4NC=CC43)C=C1
Target:
Microtubule Associated

References

Nozal V, et al. TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy. J Med Chem. 2022;65(2):1585-1607.