TargetMol

Navarixin

Product Code:
 
TAR-T7130
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7130-1mg1mg£101.00
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TAR-T7130-5mg5mg£142.00
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TAR-T7130-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T7130-10mg10mg£177.00
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TAR-T7130-25mg25mg£266.00
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TAR-T7130-50mg50mg£389.00
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TAR-T7130-100mg100mg£550.00
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TAR-T7130-500mg500mg£1,131.00
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This product comes from: United States.
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Further Information

Bioactivity:
Navarixin(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be beneficial in the treatment of conditions with unbalanced pulmonary neutrophilia.
CAS:
473727-83-2
Formula:
C21H23N3O5
Molecular Weight:
397.431
Pathway:
Autophagy; GPCR/G Protein; Immunology/Inflammation
Purity:
0.9863
SMILES:
CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccc(C)o1
Target:
CXCR

References

Gonsiorek W , Fan X , Hesk D , et al. Pharmacological Characterization of Sch527123, a Potent Allosteric CXCR1/CXCR2 Antagonist[J]. Journal of Pharmacology and Experimental Therapeutics, 2007, 322(2):477-485. Holz O, Khalilieh S, Ludwig-Sengpiel A,et al.SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects[J].Eur Respir J. 2010 Mar;35(3):564-70. Luo Q, Dong Z, Xie W, et al.Apatinib remodels the immunosuppressive tumor ecosystem of gastric cancer enhancing anti-PD-1 immunotherapy.Cell Reports.2023, 42(5).