TargetMol

LC3-mHTT-IN-AN1

Product Code:
 
TAR-T8081
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1

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CodeSizePrice
TAR-T8081-1mg1mg£166.00
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TAR-T8081-2mg2mg£205.00
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TAR-T8081-5mg5mg£275.00
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TAR-T8081-1mL1 mL * 10 mM (in DMSO)£295.00
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TAR-T8081-10mg10mg£374.00
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TAR-T8081-25mg25mg£584.00
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TAR-T8081-50mg50mg£804.00
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TAR-T8081-100mg100mg£1,058.00
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This product comes from: United States.
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Further Information

Bioactivity:
LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
CAS:
486443-73-6
Formula:
C15H9Br2NO3
Molecular Weight:
411.049
Pathway:
; Autophagy
Purity:
0.9726
SMILES:
Oc1cc(C=C2/C(=O)Nc3ccc(Br)cc23)cc(Br)c1O
Target:
Autophagy

References

Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209.