TargetMol

physalin F

Product Code:
 
TAR-T8716
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8716-1mg1mg£269.00
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TAR-T8716-5mg5mg£549.00
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TAR-T8716-1mL1 mL * 10 mM (in DMSO)£642.00
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TAR-T8716-10mg10mg£764.00
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TAR-T8716-25mg25mg£1,099.00
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TAR-T8716-50mg50mg£1,452.00
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TAR-T8716-100mg100mg£1,942.00
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Further Information

Bioactivity:
Physalin F is a natural blocker of CaV2.3 (R-type) and CaV2.2 (N-type) voltage-gated calcium channels.It is a secosteroid with potent anti-inflammatory and immunomodulatory activities. Physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by Human T-lymphotropic virus type 1 (HTLV-1) infection
CAS:
57423-71-9
Formula:
C28H30O10
Molecular Weight:
526.538
Pathway:
Apoptosis
Purity:
0.9961
SMILES:
[H][C@@]12C(=O)[C@]34O[C@@]11[C@](O)(CC[C@@]5([H])[C@@]3([H])C[C@H]3O[C@]33CC=CC(=O)[C@]53C)C(=O)O[C@@]1(C)[C@H]1C[C@]2(C)[C@@]([H])(CO4)C(=O)O1
Target:
Apoptosis

References

Pinto L A , Meira, C?ssio S, Villarreal C F , et al. Physalin F, a seco-steroid from Physalis angulata L. has immunosuppressive activity in peripheral blood mononuclear cells from patients with HTLV1-associated myelopathy[J]. Biomedicine & Pharmacotherapy, 2016, 79:129-134. Ooi K L , Tengku Muhammad T S , Sulaiman S F . Physalin F from Physalis minima L. triggers apoptosis-based cytotoxic mechanism in T-47D cells through the activation caspase-3- and c-myc-dependent pathways[J]. Journal of Ethnopharmacology, 2013, 150(1):382-388.