TargetMol

MRTX9768

Product Code:
 
TAR-T9575
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9575-1mg1mg£342.00
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TAR-T9575-5mg5mg£643.00
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TAR-T9575-10mg10mg£978.00
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TAR-T9575-25mg25mg£1,428.00
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TAR-T9575-50mg50mg£1,894.00
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Quantity:
TAR-T9575-100mg100mg£2,456.00
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This product comes from: United States.
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Further Information

Bioactivity:
MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.
CAS:
2629314-68-5
Formula:
C24H17FN6O
Molecular Weight:
424.43
Pathway:
Chromatin/Epigenetic
Purity:
0.9848
SMILES:
FC1=C(C2=C(C3=CC=C(C(NN=C4CN)=O)C4=C3)C=NN2C)C(C#N)=C(C=CC=C5)C5=C1
Target:
Histone Methyltransferase

References

Christopher R. Smith, et al. Abstract LB003: Fragment based discovery of MRTX9768, a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors. Cancer Res 1 July 2021; 81 (13_Supplement): LB003. Yingqing Chen, et al. Targeting protein arginine methyltransferase 5 in cancers: Roles, inhibitors and mechanisms. Biomed Pharmacother. 2021 Oct 4;144:112252.