TargetMol

CLEFMA

Product Code:
 
TAR-T9582
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9582-1mg1mg£189.00
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TAR-T9582-5mg5mg£340.00
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TAR-T9582-1mL1 mL * 10 mM (in DMSO)£378.00
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TAR-T9582-10mg10mg£470.00
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TAR-T9582-25mg25mg£707.00
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TAR-T9582-50mg50mg£978.00
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TAR-T9582-100mg100mg£1,291.00
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TAR-T9582-500mg500mg£2,456.00
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Further Information

Bioactivity:
CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
CAS:
1246964-32-8
Formula:
C23H17Cl2NO4
Molecular Weight:
442.29
Pathway:
NF-κb
Purity:
0.98
SMILES:
OC(/C=CC(N(C/C(/C1=O)=Cc(cccc2)c2Cl)C/C1=Cc(cccc1)c1Cl)=O)=O
Target:
NF-κB

References

Lagisetty P, et, al. CLEFMA-an anti-proliferative curcuminoid from structure-activity relationship studies on 3,5-bis(benzylidene)-4-piperidones. Bioorg Med Chem. 2010 Aug 15; 18(16):6109-20. Yadav VR, et, al. Preclinical evaluation of 4-[3,5-bis(2-chlorobenzylidene)-4-oxo-piperidine-1-yl]-4-oxo-2-butenoic acid, in a mouse model of lung cancer xenograft. Br J Pharmacol. 2013 Dec; 170(7): 1436-48.