TargetMol

Sangivamycin

Product Code:
 
TAR-T9605
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T9605-1mg1mg£173.00
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TAR-T9605-5mg5mg£349.00
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TAR-T9605-1mL1 mL * 10 mM (in DMSO)£377.00
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TAR-T9605-10mg10mg£495.00
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TAR-T9605-25mg25mg£760.00
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TAR-T9605-50mg50mg£1,026.00
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Quantity:
TAR-T9605-100mg100mg£1,340.00
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This product comes from: United States.
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Further Information

Bioactivity:
Sangivamycin is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.
CAS:
18417-89-5
Formula:
C12H15N5O5
Molecular Weight:
309.28
Pathway:
Cytoskeletal Signaling; Chromatin/Epigenetic; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Purity:
0.9811
SMILES:
NC(c1cn([C@@H]([C@@H]2O)O[C@H](CO)[C@H]2O)c2ncnc(N)c12)=O
Target:
Nucleoside Antimetabolite/Analog; PKC

References

Lee SA, et al. The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation. J Biol Chem. 2007;282(20):15271-15283. Loomis CR, Bell RM. Sangivamycin, a nucleoside analogue, is a potent inhibitor of protein kinase C. J Biol Chem. 1988;263(4):1682-1692.