TargetMol

Febrifugine dihydrochloride

Product Code:
 
TAR-TN1012L
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-TN1012L-5mg5mg£184.00
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Further Information

Bioactivity:
Febrifugine dihydrochloride is a biochemical with therapeutic activity regarding malaria, cancer, fibrosis and inflammatory diseases.
CAS:
32434-42-7
Formula:
C16H21Cl2N3O3
Molecular Weight:
374.26
Pathway:
Microbiology/Virology
Purity:
0.98
SMILES:
Cl.Cl.O[C@H]1CCCN[C@@H]1CC(=O)Cn1cnc2ccccc2c1=O
Target:
Parasite

References

Jiang S, Zeng Q, Gettayacamin M, Tungtaeng A, Wannaying S, Lim A, Hansukjariya P, Okunji CO, Zhu S, Fang D. Antimalarial activities and therapeutic properties of febrifugine analogs. Antimicrob Agents Chemother. 2005 Mar;49(3):1169-76. PubMed PMID: 15728920; PubMed Central PMCID: PMC549280. Smullen S, McLaughlin NP, Evans P. Chemical synthesis of febrifugine and analogues. Bioorg Med Chem. 2018 May 15;26(9):2199-2220. doi: 10.1016/j.bmc.2018.04.027. Epub 2018 Apr 12. Review. PubMed PMID: 29681487. Kikuchi H, Horoiwa S, Kasahara R, Hariguchi N, Matsumoto M, Oshima Y. Synthesis of febrifugine derivatives and development of an effective and safe tetrahydroquinazoline-type antimalarial. Eur J Med Chem. 2014 Apr 9;76:10-9. doi: 10.1016/j.ejmech.2014.01.036. Epub 2014 Jan 25. PubMed PMID: 24565569.