TargetMol

Afzelin

Product Code:
 
TAR-TN1362
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN1362-5mg5mg£174.00
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Further Information

Bioactivity:
Afzelin has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protect human skin from UVB-induced damage by a combination of UV-absorbing and cellular activities. Afzelin attenuates the mitochondrial damage, enhances mitochondrial biogenesis and decreases the level of mitophagy-related proteins, parkin and PTEN-induced putative kinase 1.
CAS:
482-39-3
Formula:
C21H20O10
Molecular Weight:
432.381
Pathway:
Autophagy; Apoptosis; MAPK; Metabolism; GPCR/G Protein; PI3K/Akt/mTOR signaling; Microbiology/Virology; Immunology/Inflammation
Purity:
0.98
SMILES:
C[C@@H]1O[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)cc2)[C@H](O)[C@H](O)[C@H]1O
Target:
PTEN; p38 MAPK; TNF; Mitochondrial Metabolism; Antibacterial; Prostaglandin Receptor; Autophagy

References

Shin SW, et al. Antagonizing effects and mechanisms of afzelin against UVB-induced cell damage. PLoS One. 2013 Apr 23;8(4):e61971. Lee SB, et al. Afzelin ameliorates D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure by modulating mitochondrial quality control and dynamics. Br J Pharmacol. 2017 Jan;174(2):195-209.