TargetMol

Isotetrandrine

Product Code:
 
TAR-TN1806
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN1806-5mg5mg£503.00
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Quantity:
TAR-TN1806-1mL1 mL * 10 mM (in DMSO)£994.00
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Further Information

Bioactivity:
Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of LPS-induced ALI by inactivation of MAPK and NF-κB, which may involve the inhibition of tissue oxidative injury and pulmonary inflammatory process.
CAS:
477-57-6
Formula:
C38H42N2O6
Molecular Weight:
622.762
Pathway:
MAPK; NF-κb; Immunology/Inflammation
Purity:
0.98
SMILES:
COc1ccc2C[C@H]3N(C)CCc4cc(OC)c(OC)c(Oc5cc6[C@H](Cc7ccc(Oc1c2)cc7)N(C)CCc6cc5OC)c34
Target:
IL Receptor; NF-κB; MAPK

References

Isotetrandrine protects against lipopolysaccharide-induced acute lung injury by suppression of mitogen-activated protein kinase and nuclear factor-kappa B.J Surg Res. 2014 Apr;187(2):596-604.