TargetMol

Isochamaejasmine

Product Code:
 
TAR-TN4271
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TN4271-1mg1mg£466.00
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Further Information

Bioactivity:
Isochamaejasmine is a biflavonoid isolated from S. chamaejasme L. with inhibition of NF-κB activation. Isochamaejasmine induces apoptosis in leukemia cells by inhibiting the activity of Bcl-2 family proteins and can be used in anti-cancer studies.
CAS:
93859-63-3
Formula:
C30H22O10
Molecular Weight:
542.49
Pathway:
Chromatin/Epigenetic; MAPK; Proteases/Proteasome; Microbiology/Virology; DNA Damage/DNA Repair; Cytoskeletal Signaling; Apoptosis
Purity:
0.98
SMILES:
O=C1[C@]([C@@H](OC=2C1=C(O)C=C(O)C2)C3=CC=C(O)C=C3)([C@@]4([C@H](OC=5C(C4=O)=C(O)C=C(O)C5)C6=CC=C(O)C=C6)[H])[H]
Target:
ERK; BCL; PARP; p38 MAPK; Caspase; PKC; Antifection

References

Qinghai Tian, et al. Stereospecific induction of nuclear factor-kappaB activation by isochamaejasmin. Mol Pharmacol. 2005 Dec;68(6):1534-42. Liene Dhooghe, et al. Antiplasmodial activity of (I-3,II-3)-biflavonoids and other constituents from Ormocarpum kirkii. Phytochemistry. 2010 May;71(7):785-91.