TargetMol

MM 54

Product Code:
 
TAR-TP2001
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TP2001-1mg1mg£270.00
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Further Information

Bioactivity:
Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens survival time in a mouse xenograft model of glioblastoma.
CAS:
1313027-43-8
Formula:
C70H121N29O15S4
Molecular Weight:
1737.15
Purity:
0.98
SMILES:
0

References

Harford-Wright et al (2017) Pharmacological targeting of apelin impairs glioblastoma growth. Brain 140 2939 PMID: Macaluso et al (2011) Discovery of a competitive apelin receptor (APJ) antagonist. ChemMedChem 6 1017 PMID: