TargetMol

MK-6892

Product Code:
 
TAR-TQ0108
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TQ0108-1mg1mg£163.00
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TAR-TQ0108-5mg5mg£269.00
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TAR-TQ0108-1mL1 mL * 10 mM (in DMSO)£279.00
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TAR-TQ0108-10mg10mg£356.00
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TAR-TQ0108-25mg25mg£549.00
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TAR-TQ0108-50mg50mg£744.00
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TAR-TQ0108-100mg100mg£1,002.00
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TAR-TQ0108-500mg500mg£1,934.00
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This product comes from: United States.
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Further Information

Bioactivity:
MK-6892 is a selective and full agonist for the high-affinity nicotinic acid receptor GPR109A (Ki: 4 nM; GTPγS EC50: 16 nM).
CAS:
917910-45-3
Formula:
C19H22N4O5
Molecular Weight:
386.408
Pathway:
GPCR/G Protein; Endocrinology/Hormones
Purity:
0.9903
SMILES:
CC(C)(Cc1nc(no1)-c1ccc(O)cn1)C(=O)NC1=C(CCCC1)C(O)=O
Target:
GPR

References

Zhu S, Yuan Q, Li X, et al.Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2.Cell Reports.2023, 42(11). Shen HC, et al. Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. J Med Chem. 2010 Mar 25;53(6):2666-70. Kim HY, et al. Discovery of 4-(phenyl)thio-1H-pyrazole derivatives as agonists of GPR109A, a high affinity niacin receptor. Arch Pharm Res. 2015 Jun;38(6):1019-32.