TargetMol

Salinomycin

Product Code:
 
TAR-T0906
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T0906-1mg1mg£96.00
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TAR-T0906-2mg2mg£107.00
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TAR-T0906-5mg5mg£130.00
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TAR-T0906-10mg10mg£165.00
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TAR-T0906-1mL1 mL * 10 mM (in DMSO)£173.00
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TAR-T0906-25mg25mg£246.00
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TAR-T0906-50mg50mg£383.00
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TAR-T0906-100mg100mg£519.00
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Further Information

Bioactivity:
Salinomycin, a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin (Procoxacin) shows selective activity against human cancer stem cells.
CAS:
53003-10-4
Formula:
C42H70O11
Molecular Weight:
751
Pathway:
Cytoskeletal Signaling; Stem Cells; Microbiology/Virology
Purity:
0.98
SMILES:
CC[C@H](C1OC([C@@H](C)CC1)[C@@H](C)[C@H](O)[C@H](C)C([C@H](CC)C2O[C@@]3([C@H](C)C[C@@H]2C)C=C[C@@H](O)[C@@]4(O[C@@](C5O[C@@H](C)[C@@](O)(CC)CC5)(C)CC4)O3)=O)C(O)=O
Target:
Wnt/beta-catenin; Antibacterial

References

1. Lu D, et al. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13253-7. 2. Zhou J, et al. Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactiveoxygen species. Toxicol Lett. 2013 Oct 24;222(2):139-45. 3. Klose J, et al. Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model. PLoS One. 2019 Feb 14;14(2):e0211916. 4. Wang F, et al. Salinomycin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells In Vitro and In Vivo. PLoS One. 2012; 7(12): e50638. 5. Qu H, et al. Effect of salinomycin on metastasis and invasion of bladder cancer cell line T24. Asian Pac J Trop Med. 2015 Jul;8(7):578-82. 6. Naujokat C, et al. Salinomycin as a drug for targeting human cancer stem cells. J Biomed Biotechnol. 2012;2012:950658.