TargetMol

A 1070722

Product Code:
 
TAR-T10202
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10202-5mg5mg£121.00
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TAR-T10202-1mL1 mL * 10 mM (in DMSO)£125.00
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TAR-T10202-10mg10mg£148.00
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TAR-T10202-25mg25mg£229.00
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TAR-T10202-50mg50mg£357.00
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TAR-T10202-100mg100mg£499.00
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Further Information

Bioactivity:
A 1070722 is a potent and selective GSK-3 inhibitor, shows high affinity GSK-3α(Ki = 0.6 nM) and GSK-3β(Ki = 0.6 nM). It can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain.
CAS:
1384424-80-9
Formula:
C17H13F3N4O2
Molecular Weight:
362.312
Pathway:
PI3K/Akt/mTOR signaling; Stem Cells
Purity:
0.98
SMILES:
COc1ccc2c(NC(=O)Nc3cccc(n3)C(F)(F)F)ccnc2c1
Target:
GSK-3

References

1. Prabhakaran J, et al. Radiosynthesis and in Vivo Evaluation of [11C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain. ACS Chem Neurosci. 2017 Aug 16;8(8):1697-1703.